1-Methylpiperazin-2-one--hydrogen chloride (1/1) → HCID 50912875, compound

HRID 1942089Notes

Reaction equation

HRID 1942089 reaction equation
Cl[C:2]1[CH:3]=[CH:4][C:5]2[N:6]([C:8]([CH:11]([C:13]3[CH:14]=[C:15]4[C:20](=[CH:21][C:22]=3[F:23])[N:19]=[CH:18][CH:17]=[CH:16]4)[CH3:12])=[CH:9][N:10]=2)[N:7]=1.Cl.[CH3:25][N:26]1[CH2:31][CH2:30][NH:29][CH2:28][C:27]1=[O:32]>>[F:23][C:22]1[CH:21]=[C:20]2[C:15]([CH:16]=[CH:17][CH:18]=[N:19]2)=[CH:14][C:13]=1[CH:11]([C:8]1[N:6]2[N:7]=[C:2]([N:29]3[CH2:30][CH2:31][N:26]([CH3:25])[C:27](=[O:32])[CH2:28]3)[CH:3]=[CH:4][C:5]2=[N:10][CH:9]=1)[CH3:12]

Participants

3

Reactant 2

HCID 170607661-Methylpiperazin-2-one--hydrogen chloride (1/1)HCID 581475216-(1-(6-Chloroimidazo[1,2-b]pyridazin-3-yl)ethyl)-7-fluoroquinoline2×

Product 1

HCID 50912875HCID 50912875, compound

Procedure

The title compound was prepared in analogy to Example 38 using (rac)-6-[1-(6-chloro-imidazo[1,2-b]pyridazin-3-yl)ethyl]-7-fluoro-quinoline (Intermediate K, 50 mg, 0.153 mmol), 1-methylpiperazin-2-one hydrochloride (46.1 mg, 0.306 mmol) (tR 3.24 min (conditions 5), MH+=404, 1H-NMR in DMSO-d6: 8.83 (d, 1H); 8.28 (d, 1H); 7.84 (s, 1H); 7.81 (d, 1H); 7.72 (d, 1H); 7.56 (s, 1H); 7.43 (m, 1H); 7.11 (d, 1H); 4.88 (m, 1H); 3.98 (d, 1H); 3.83 (m, 1H); 3.25 (m, 2H); 2.77 (s, 3H); 1.78 (d, 3H)).

Sources & evidence

ORD record
ord-cb332a847e064ac2b0f46b0f405bde97
Source dataset
uspto-grants-2013_03
Patent number
US08389526B2

Reaction notes

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