1-Methylpiperazin-2-one--hydrogen chloride (1/1) → HCID 50912875, compound

Participants

Reaction Steps

The title compound was prepared in analogy to Example 38 using (rac)-6-[1-(6-chloro-imidazo[1,2-b]pyridazin-3-yl)ethyl]-7-fluoro-quinoline (Intermediate K, 50 mg, 0.153 mmol), 1-methylpiperazin-2-one hydrochloride (46.1 mg, 0.306 mmol) (tR 3.24 min (conditions 5), MH+=404, 1H-NMR in DMSO-d6: 8.83 (d, 1H); 8.28 (d, 1H); 7.84 (s, 1H); 7.81 (d, 1H); 7.72 (d, 1H); 7.56 (s, 1H); 7.43 (m, 1H); 7.11 (d, 1H); 4.88 (m, 1H); 3.98 (d, 1H); 3.83 (m, 1H); 3.25 (m, 2H); 2.77 (s, 3H); 1.78 (d, 3H)).

Provenance & Evidence