1-Methylpiperazin-2-one--hydrogen chloride (1/1) → HCID 50912878, compound

HRID 1942091Notes

Reaction equation

HRID 1942091 reaction equation
Cl[C:2]1[CH:3]=[CH:4][C:5]2[N:6]([C:8]([CH2:11][C:12]3[C:13]([F:22])=[C:14]4[C:19](=[CH:20][CH:21]=3)[N:18]=[CH:17][CH:16]=[CH:15]4)=[CH:9][N:10]=2)[N:7]=1.Cl.[CH3:24][N:25]1[CH2:30][CH2:29][NH:28][CH2:27][C:26]1=[O:31]>>[F:22][C:13]1[C:12]([CH2:11][C:8]2[N:6]3[N:7]=[C:2]([N:28]4[CH2:29][CH2:30][N:25]([CH3:24])[C:26](=[O:31])[CH2:27]4)[CH:3]=[CH:4][C:5]3=[N:10][CH:9]=2)=[CH:21][CH:20]=[C:19]2[C:14]=1[CH:15]=[CH:16][CH:17]=[N:18]2

Participants

3

Reactant 2

HCID 170607661-Methylpiperazin-2-one--hydrogen chloride (1/1)HCID 58147543HCID 58147543, compound2×

Product 1

HCID 50912878HCID 50912878, compound

Procedure

The title compound was prepared in analogy to Example 38 using 6-(6-chloro-imidazo[1,2-b]pyridazin-3-ylmethyl)-5-fluoro-quinoline (Intermediate N, 70 mg, 0.224 mmol), 1-methylpiperazin-2-one hydrochloride (67.4 mg, 0.448 mmol) (tR 3.31 min (conditions 5), MH+=391, 1H-NMR in DMSO-d6: 8.91 (m, 1H); 8.47 (d, 1H); 7.85 (d, 1H); 7.78 (d, 1H); 7.69 (d, 1H); 7.66 (s, 1H); 7.61 (m, 1H); 7.50 (s, 1H); 4.42 (s, 2H); 4.03 (s, 2H); 3.74 (m, 2H); 3.35 (m, 2H); 2.84 (s, 3H)).

Sources & evidence

ORD record
ord-b0efdd41d97f4890bb74625a939474a2
Source dataset
uspto-grants-2013_03
Patent number
US08389526B2

Reaction notes

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