1-Methylpiperazin-2-one--hydrogen chloride (1/1) → HCID 50912878, compound

Participants

Reaction Steps

The title compound was prepared in analogy to Example 38 using 6-(6-chloro-imidazo[1,2-b]pyridazin-3-ylmethyl)-5-fluoro-quinoline (Intermediate N, 70 mg, 0.224 mmol), 1-methylpiperazin-2-one hydrochloride (67.4 mg, 0.448 mmol) (tR 3.31 min (conditions 5), MH+=391, 1H-NMR in DMSO-d6: 8.91 (m, 1H); 8.47 (d, 1H); 7.85 (d, 1H); 7.78 (d, 1H); 7.69 (d, 1H); 7.66 (s, 1H); 7.61 (m, 1H); 7.50 (s, 1H); 4.42 (s, 2H); 4.03 (s, 2H); 3.74 (m, 2H); 3.35 (m, 2H); 2.84 (s, 3H)).

Provenance & Evidence