Piperazin-2-one → HCID 50913012, compound

HRID 1942092Notes

Reaction equation

HRID 1942092 reaction equation
Cl[C:2]1[CH:3]=[CH:4][C:5]2[N:6]([C:8]([CH2:11][C:12]3[C:13]([F:22])=[C:14]4[C:19](=[CH:20][CH:21]=3)[N:18]=[CH:17][CH:16]=[CH:15]4)=[CH:9][N:10]=2)[N:7]=1.[NH:23]1[CH2:28][CH2:27][NH:26][CH2:25][C:24]1=[O:29]>>[F:22][C:13]1[C:12]([CH2:11][C:8]2[N:6]3[N:7]=[C:2]([N:26]4[CH2:27][CH2:28][NH:23][C:24](=[O:29])[CH2:25]4)[CH:3]=[CH:4][C:5]3=[N:10][CH:9]=2)=[CH:21][CH:20]=[C:19]2[C:14]=1[CH:15]=[CH:16][CH:17]=[N:18]2

Participants

3

Reactant 2

HCID 231360Piperazin-2-oneHCID 58147543HCID 58147543, compound2×

Product 1

HCID 50913012HCID 50913012, compound

Procedure

The title compound was prepared in analogy to Example 38 6-(6-chloro-imidazo[1,2-b]pyridazin-3-ylmethyl)-5-fluoro-quinoline (Intermediate N, 100 mg, 0.320 mmol), piperazin-2-one (96 mg, 0.959 mmol) (tR 3.16 min (conditions 5), MH+=377, 1H-NMR in DMSO-d6: 8.91 (m, 1H); 8.47 (d, 1H); 8.07 (s, 1H); 7.84 (d, 1H); 7.78 (d, 1H); 7.69 (m, 1H); 7.60 (m, 1H); 7.47 (s, 1H); 7.12 (d, 1H); 4.42 (s, 2H); 3.98 (s, 2H); 3.66 (m, 2H); 3.25 (m, 4H)).

Sources & evidence

ORD record
ord-a9ab01e47e29410ca3cd205bed7c24fe
Source dataset
uspto-grants-2013_03
Patent number
US08389526B2

Reaction notes

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