Piperazin-2-one → HCID 50913012, compound

Participants

Reaction Steps

The title compound was prepared in analogy to Example 38 6-(6-chloro-imidazo[1,2-b]pyridazin-3-ylmethyl)-5-fluoro-quinoline (Intermediate N, 100 mg, 0.320 mmol), piperazin-2-one (96 mg, 0.959 mmol) (tR 3.16 min (conditions 5), MH+=377, 1H-NMR in DMSO-d6: 8.91 (m, 1H); 8.47 (d, 1H); 8.07 (s, 1H); 7.84 (d, 1H); 7.78 (d, 1H); 7.69 (m, 1H); 7.60 (m, 1H); 7.47 (s, 1H); 7.12 (d, 1H); 4.42 (s, 2H); 3.98 (s, 2H); 3.66 (m, 2H); 3.25 (m, 4H)).

Provenance & Evidence