1-Acetylpiperazine → HCID 50913013, compound

HRID 1942093Notes

Reaction equation

HRID 1942093 reaction equation
Cl[C:2]1[CH:3]=[CH:4][C:5]2[N:6]([C:8]([CH2:11][C:12]3[C:13]([F:22])=[C:14]4[C:19](=[CH:20][CH:21]=3)[N:18]=[CH:17][CH:16]=[CH:15]4)=[CH:9][N:10]=2)[N:7]=1.[C:23]([N:26]1[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]1)(=[O:25])[CH3:24]>>[F:22][C:13]1[C:12]([CH2:11][C:8]2[N:6]3[N:7]=[C:2]([N:29]4[CH2:30][CH2:31][N:26]([C:23](=[O:25])[CH3:24])[CH2:27][CH2:28]4)[CH:3]=[CH:4][C:5]3=[N:10][CH:9]=2)=[CH:21][CH:20]=[C:19]2[C:14]=1[CH:15]=[CH:16][CH:17]=[N:18]2

Participants

3

Reactant 2

HCID 837951-AcetylpiperazineHCID 58147543HCID 58147543, compound2×

Product 1

HCID 50913013HCID 50913013, compound

Procedure

The title compound was prepared in analogy to Example 38 using 6-(6-chloro-imidazo[1,2-b]pyridazin-3-ylmethyl)-5-fluoro-quinoline (Intermediate N, 70 mg, 0.224 mmol) and 1-acetylpiperazine (57.4 mg, 0.448 mmol) (tR 3.40 min (conditions 5), MH+=405, 1H-NMR in DMSO-d6: 8.92 (m, 1H); 8.49 (d, 1H); 7.83 (d, 1H); 7.79 (d, 1H); 7.67 (m, 1H); 7.61 (m, 1H); 7.45 (s, 1H); 7.13 (d, 1H); 4.41 (s, 2H); 3.47 (s, 4H); 3.41 (m, 1H); 3.28 (m, 1H); 2.00 (s, 3H)).

Sources & evidence

ORD record
ord-62db5d55031a4093a858e9bd6079213e
Source dataset
uspto-grants-2013_03
Patent number
US08389526B2

Reaction notes

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