1-Acetylpiperazine → HCID 50913013, compound

Participants

Reaction Steps

The title compound was prepared in analogy to Example 38 using 6-(6-chloro-imidazo[1,2-b]pyridazin-3-ylmethyl)-5-fluoro-quinoline (Intermediate N, 70 mg, 0.224 mmol) and 1-acetylpiperazine (57.4 mg, 0.448 mmol) (tR 3.40 min (conditions 5), MH+=405, 1H-NMR in DMSO-d6: 8.92 (m, 1H); 8.49 (d, 1H); 7.83 (d, 1H); 7.79 (d, 1H); 7.67 (m, 1H); 7.61 (m, 1H); 7.45 (s, 1H); 7.13 (d, 1H); 4.41 (s, 2H); 3.47 (s, 4H); 3.41 (m, 1H); 3.28 (m, 1H); 2.00 (s, 3H)).

Provenance & Evidence