(3-Methyloxetan-3-yl)methanamine → (3-Methyl-oxetan-3-ylmethyl)-(5-phenylethynyl-pyrimidin-2-yl)-amine

HRID 1942185Notes

Reaction equation

HRID 1942185 reaction equation
CS([C:5]1[N:10]=[CH:9][C:8]([C:11]#[C:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[CH:7][N:6]=1)(=O)=O.[CH3:19][C:20]1([CH2:24][NH2:25])[CH2:23][O:22][CH2:21]1>>[CH3:19][C:20]1([CH2:24][NH:25][C:5]2[N:10]=[CH:9][C:8]([C:11]#[C:12][C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)=[CH:7][N:6]=2)[CH2:23][O:22][CH2:21]1

Participants

3

Reactant 2

HCID 15789550(3-Methyloxetan-3-yl)methanamineHCID 575167582-Methanesulfonyl-5-phenylethynyl-pyrimidine

Product 1

HCID 52917188(3-Methyl-oxetan-3-ylmethyl)-(5-phenylethynyl-pyrimidin-2-yl)-amine

Procedure

The title compound, white solid, MS: m/e=280.2 (M+H+), can be prepared in accordance with the general method of example 1, step 3 from 2-methanesulfonyl-5-phenylethynyl-pyrimidine (example 1, step 2) and (3-methyloxetan-3-yl)methanamine.

Sources & evidence

ORD record
ord-22f223d690914d17b36c561dccdc06dc
Source dataset
uspto-grants-2013_03
Patent number
US08389536B2

Reaction notes

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