化工社化工社 化学情報印刷レポート · 研究参考用
Bromoacetic Acid → [2-(4-Cyclopropyl-phenyl)-1-oxo-2,8-diaza-spiro[4.5]dec-8-yl]-acetic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Bromoacetic Acid | HCID 6227 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 2-(4-Cyclopropyl-phenyl)-2,8-diaza-spiro[4.5]decan-1-one | HCID 58287277 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | [2-(4-Cyclopropyl-phenyl)-1-oxo-2,8-diaza-spiro[4.5]dec-8-yl]-acetic acid | HCID 58287265 | — |
反応手順
A mixture of 0.4 g (1.47 mmol) 2-(4-Cyclopropyl-phenyl)-2,8-diaza-spiro[4.5]decan-1-one, 0.226 g (1.63 mmol) bromoacetic acid and 0.299 g (2.96 mmol) NEt3 in 50 mL DCM was stirred at room temperature for 16 h. The mixture was concentrated and used without further purification in the consecutive step. MS m/e: 329.3 [M+H]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08389539B2 |
| 出典データセット | uspto-grants-2013_03 |
| ORD ID | ord-8ceeb87a442c4cdab5a5335e0eb4f048 |
| 出典メモ | uspto-grants-2013_03 |