反应详情

温度

22 °C

A mixture of 320 mg (1.24 mmol) 2-(4-ethylphenyl)-2,8-diazaspiro[4.5]decan-1-one, 431 mg (1.61 mmol) 2-bromo-1-(2,4-dichlorophenyl)ethanone and 376 mg (3.72 mmol) triethylamine in 50 mL DCM was stirred at 22° C. for 16 h. The crude reaction mixture was concentrated in vacuo. The crude material was purified by flash chromatography on silica eluting with a gradient formed from ethyl acetate and heptane to yield after evaporation of the product containing fractions 435 mg (79%) of the title compound as orange solid. MS m/e: 445.2 [M+H]+.

1. customThe crude reaction mixture
2. concentrationwas concentrated in vacuo
3. customThe crude material was purified by flash chromatography on silica eluting with a gradient
4. customformed from ethyl acetate and heptane
5. customto yield
6. customafter evaporation of the product
7. additioncontaining fractions 435 mg (79%) of the title compound as orange solid