反应详情

温度

0 °C

To a well stirred suspension of sodium borohydride (66.21 g, 1.75 mole) in methanol (3.5 L) cooled to 0° C. with a Dry Ice/acetone bath was added 1-(5,6-dichloro-pyridin-3-yl)-ethanone 14 (665 g, 3.5 mole) at a rate such that the temperature remained at 0° C. After solid addition was complete, the reaction mixture was stirred an additional 1 h, after which time LC/MS analysis of an aliquot showed that the reaction was complete.

1. customremained at 0° C
2. additionAfter solid addition
3. stirringthe reaction mixture was stirred an additional 1 h