HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1942263Generated: November 1, 2026
Sodium borohydride → 1-(5,6-Dichloro-pyridin-3-yl)-ethanol
https://huagongshe.com/reaction/1942263
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | 1-(5,6-Dichloropyridin-3-yl)ethan-1-one | HCID 10198006 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-(5,6-Dichloro-pyridin-3-yl)-ethanol | HCID 11593582 | — |
Reaction Steps
To a well stirred suspension of sodium borohydride (66.21 g, 1.75 mole) in methanol (3.5 L) cooled to 0° C. with a Dry Ice/acetone bath was added 1-(5,6-dichloro-pyridin-3-yl)-ethanone 14 (665 g, 3.5 mole) at a rate such that the temperature remained at 0° C. After solid addition was complete, the reaction mixture was stirred an additional 1 h, after which time LC/MS analysis of an aliquot showed that the reaction was complete.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08389549B2 |
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| Source dataset | uspto-grants-2013_03 |
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| ORD ID | ord-cfc05fd34df94ca4bcf4a2f634328554 |
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| Source note | uspto-grants-2013_03 |
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