2-Propanol, 1-amino-2-methyl- → HCID 46872754, compound

HRID 1942282Notes

Reaction equation

CO[C:3](=[O:22])[C:4]1[CH:9]=[CH:8][C:7](/[CH:10]=[CH:11]/[C:12]2[C:13]([CH2:18][CH2:19][CH2:20][CH3:21])=[N:14][O:15][C:16]=2[CH3:17])=[N:6][CH:5]=1.[NH2:23][CH2:24][C:25]([CH3:28])([OH:27])[CH3:26]>>[CH2:18]([C:13]1[C:12](/[CH:11]=[CH:10]/[C:7]2[CH:8]=[CH:9][C:4]([C:3]([NH:23][CH2:24][C:25]([OH:27])([CH3:28])[CH3:26])=[O:22])=[CH:5][N:6]=2)=[C:16]([CH3:17])[O:15][N:14]=1)[CH2:19][CH2:20][CH3:21]

Participants

Reactant 2

HCID 951022-Propanol, 1-amino-2-methyl-

HCID 46872756HCID 46872756, compound

Product 1

HCID 46872754HCID 46872754, compoundYield 7%

Procedure

As described in example 10, 6-[(E)-2-(3-butyl-5-methyl-isoxazol-4-yl)-vinyl]-nicotinic acid methyl ester (100 mg, 0.28 mmol), and 1-amino-2-methyl-propan-2-ol instead of DL-2-amino-1-propanol, was converted to the title compound (7.5 mg, 7%) which was obtained as a colorless solid after purification by chromatography (silica, dichloromethane:methanol 100:0 to 94:6). MS: m/e=364.4 [M+H]+.

Sources & evidence

ORD record: ord-731d4ffa291840ffb1cc869df64ef369
Source dataset: uspto-grants-2013_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08389550B2

Reaction notes

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