2-Propanol, 1-amino-2-methyl- → HCID 46872754, compound

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Reaction Steps

As described in example 10, 6-[(E)-2-(3-butyl-5-methyl-isoxazol-4-yl)-vinyl]-nicotinic acid methyl ester (100 mg, 0.28 mmol), and 1-amino-2-methyl-propan-2-ol instead of DL-2-amino-1-propanol, was converted to the title compound (7.5 mg, 7%) which was obtained as a colorless solid after purification by chromatography (silica, dichloromethane:methanol 100:0 to 94:6). MS: m/e=364.4 [M+H]+.

Provenance & Evidence