反应详情

温度

70 °C

A mixture of (+)-methyl{(2S,4R)-2-[4-(trifluoromethyl)phenyl]piperidin-4-yl}acetate (Intermediate 2, 3.02 g, 10.0 mmol), 4-methylpentanal (2.1 g, 20.9 mmol) and gold (III) bromide (440 mg, 1 mmol) were combined in water (10 ml) in a 20 ml microwave vial. After the mixture was deoxygenated by evacuate/fill N2, 2-methylbut-1-en-3-yne (1.9 ml, 20.4 mmol) was added. The reaction was stirred and heated a 70° C. in the microwave for 30 min. The mixture was diluted with MeOH and loaded onto 5 SCX cartridges (10 g). Each cartridge was washed with MeOH (50 ml) then 2M NH3 in MeOH (2×50 ml). The ammonia-methanol fractions were combined and evaporated. The residue was taken up in EtOAc and washed with brine (×1), then dried (Na2SO4), filtered and evaporated. The residue was combined with the product from a repeat experiment on the same scale and purified by chromatography (silica, 10% Et2O/isohexane) to give the alkyne (9.1 g) a light yellow oil. 1H NMR (500 MHz, CDCl3): δ 0.83 (6H, d, J 6.6), 1.07-1.22 (2H, m), 1.27-1.45 (3H, m), 1.51-1.58 (2H, m), 1.77-1.85 (2H, m), 1.91 (3H, s), 1.93-2.02 (1H, m), 2.19-2.29 (2H, m), 2.40-2.46 (1H, m), 2.94-2.98 (1H, m), 3.18 (1H, t, J 7.6), 3.50 (1H, dd, J 2.7, 11.2), 3.65 (3H, s), 5.19 (1H, m), 5.25 (1H, s), 7.45 (2H, d, J 7.4), 7.56 (2H, d, J 8.2); M/Z (ES+) 420 (MH+).

1. customAfter the mixture was deoxygenated
2. additionwas added
3. washEach cartridge was washed with MeOH (50 ml)
4. customevaporated
5. washwashed with brine (×1)
6. dry with materialdried (Na2SO4)
7. filtrationfiltered
8. customevaporated
9. custompurified by chromatography (silica, 10% Et2O/isohexane)