Propylamine → Imidazo[2,1-b][1,3,4]thiadiazol-2-yl-propyl-amine

HRID 1942315Notes

Reaction equation

HRID 1942315 reaction equation
Br[C:2]1[S:6][C:5]2=[N:7][CH:8]=[CH:9][N:4]2[N:3]=1.[CH2:10]([NH2:13])[CH2:11][CH3:12]>CO>[S:6]1[C:2]([NH:13][CH2:10][CH2:11][CH3:12])=[N:3][N:4]2[CH:9]=[CH:8][N:7]=[C:5]12

Participants

4

Reactant 2

HCID 7852PropylamineHCID 436679232-Bromoimidazo[2,1-b][1,3,4]thiadiazole

Product 1

HCID 58285612Imidazo[2,1-b][1,3,4]thiadiazol-2-yl-propyl-amine

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
175 °C

Procedure

1.5 g of 2-bromo-imidazo[2,1-b][1,3,4]thiadiazole were dissolved in 10 ml methanol and 10 ml of propylamine were added to the solution. The resulting mixture was heated in a microwave oven at 175° C. for 15 min. The resulting suspension was evaporated and dissolved in ethylacetate. It was washed with water, dried with sodium sulphate and evaporated. Silica-gel chromatography with petroleum ether-ethylacetate gave 519 mg of the desired product as solid material.

Workup

  1. customThe resulting suspension was evaporated
  2. dissolutiondissolved in ethylacetate
  3. washIt was washed with water
  4. dry with materialdried with sodium sulphate
  5. customevaporated

Sources & evidence

ORD record
ord-a71779027ca74748ab1bd7a9f0fe6cc0
Source dataset
uspto-grants-2013_03
Patent number
US08389554B2

Reaction notes

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