N-Iodosuccinimide → (5-Iodo-imidazo[2,1-b][1,3,4]thiadiazol-2-yl)-propyl-amine

HRID 1942316Notes

Reaction equation

HRID 1942316 reaction equation
[S:1]1[C:5]([NH:6][CH2:7][CH2:8][CH3:9])=[N:4][N:3]2[CH:10]=[CH:11][N:12]=[C:2]12.[I:13]N1C(=O)CCC1=O>C(#N)C>[I:13][C:10]1[N:3]2[C:2]([S:1][C:5]([NH:6][CH2:7][CH2:8][CH3:9])=[N:4]2)=[N:12][CH:11]=1

Participants

4

Reactant 2

HCID 120273N-IodosuccinimideHCID 58285612Imidazo[2,1-b][1,3,4]thiadiazol-2-yl-propyl-amine

Product 1

HCID 58285729(5-Iodo-imidazo[2,1-b][1,3,4]thiadiazol-2-yl)-propyl-amineYield 36.6%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

663 mg of imidazo[2,1-b][1,3,4]thiadiazol-2-yl-propyl-amine were dissolved in 20 ml of acetonitrile. 822 mg of N-iodosuccinimide were added to the solution. The reaction mixture was stirred for 4 h at room temperature. For work-up, the mixture was cooled on ice and filtrated. 410 mg of the desired product were obtained.

Workup

  1. temperatureFor work-up, the mixture was cooled on ice
  2. filtrationfiltrated

Sources & evidence

ORD record
ord-4683d2492c044513aec3142526f604e8
Source dataset
uspto-grants-2013_03
Patent number
US08389554B2

Reaction notes

Loading…