Ammonia → 1,4-Dioxaspiro[4.5]decan-8-amine

HRID 1942338Notes

Reaction equation

HRID 1942338 reaction equation

[O:1]1[C:5]2([CH2:10][CH2:9][CH:8]([NH:11]CCC)[CH2:7][CH2:6]2)[O:4][CH2:3][CH2:2]1.N>CO>[O:1]1[C:5]2([CH2:10][CH2:9][CH:8]([NH2:11])[CH2:7][CH2:6]2)[O:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 222Ammonia

HCID 118200814-n-Propylamino-cyclohexanone-ethyleneketal

Product 1

HCID 146343151,4-Dioxaspiro[4.5]decan-8-amine

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

1,4-Dioxa-spiro[4.5]dec-8-ylamine (2A) is synthesized as been described for 1A using methanol which has been saturated with ammonia.

Sources & evidence

ORD record: ord-e8687a5ae88246758ffc64d836b635a3
Source dataset: uspto-grants-2013_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08389555B2

Reaction notes

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