HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Naphthoyl chloride → N-(2-Hydroxyethyl)naphthalene-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Naphthoyl chloride | HCID 75246 | — |
| Reactant | Aminoacetaldehyde dimethyl acetal | HCID 89728 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | N-(2-Hydroxyethyl)naphthalene-2-carboxamide | HCID 13288324 | — |
Reaction Steps
To a mixture of 3.15 g (30 mmol) 2,2-dimethoxy-ethylamine and 40 mL dioxane is added 1.91 g (10 mmol) naphthalene-2-carbonyl chloride. After stirring overnight the solution is pored into 200 mL of ice water. Filtration yields the product in almost quantitative yield as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08389555B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-22dc84693c8b474c9b551faa67a61a3e |
| Source note | uspto-grants-2013_03 |