HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 5-[Propyl-(4,5,6,7-tetrahydro-benzothiazol-6-yl)-amino]-pentanoic acid naphthalen-2-ylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Propyl-(4,5,6,7-tetrahydro-benzothiazol-6-yl)-amine | HCID 18705889 | — |
| Reactant | 5-Bromo-pentanoic acid naphthalen-2-ylamide | HCID 66937445 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 5-[Propyl-(4,5,6,7-tetrahydro-benzothiazol-6-yl)-amino]-pentanoic acid naphthalen-2-ylamide | HCID 66937452 | — |
Reaction Steps
9 is prepared from 1C and 9A using the same method as for 6 with acetone as solvent and triethylamine as base. Reaction temperature is 50° C. After evaporation of the solvent the residue is suspended in water, alkalized with sodium hydroxide solution and extracted three times with dichloromethane. After evaporation of the combined organic phases the product is crystallized as salt of maleic acid from acetonitrile/diethylether.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08389555B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-72f48c4767c14a9d8d616a8a90e2683e |
| Source note | uspto-grants-2013_03 |