反应详情

9 is prepared from 1C and 9A using the same method as for 6 with acetone as solvent and triethylamine as base. Reaction temperature is 50° C. After evaporation of the solvent the residue is suspended in water, alkalized with sodium hydroxide solution and extracted three times with dichloromethane. After evaporation of the combined organic phases the product is crystallized as salt of maleic acid from acetonitrile/diethylether.

1. customReaction temperature
2. customis 50° C
3. customAfter evaporation of the solvent the residue
4. extractionextracted three times with dichloromethane
5. customAfter evaporation of the combined organic phases the product
6. customis crystallized as salt of maleic acid from acetonitrile/diethylether