HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1942397Generated: November 1, 2026
Water → 4-{[Propyl-(4,5,6,7-tetrahydro-benzothiazol-6-yl)-amino]-methyl}-benzoic acid
https://huagongshe.com/reaction/1942397
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 4-{[Propyl-(4,5,6,7-tetrahydrobenzothiazol-6-yl)amino]methyl}benzoic acid methylester | HCID 86651313 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 4-{[Propyl-(4,5,6,7-tetrahydro-benzothiazol-6-yl)-amino]-methyl}-benzoic acid | HCID 66937408 | — |
Reaction Steps
A mixture of 1.93 g (5.6 mmol) 42A, 840 mg (21 mmol) sodium hydroxide and 25 mL water is stirred for 4 hours at 80° C. The mixture is allowed to cool to room temperature and then neutralized with acetic acid and extracted three times with dichloromethane. The combined organic fractions are dried with sodium sulfate, and the solvent is evaporated in vacuum.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08389555B2 |
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| Source dataset | uspto-grants-2013_03 |
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| ORD ID | ord-7c877cc7518746599f23fd706423cb06 |
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| Source note | uspto-grants-2013_03 |
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