1,2,3,4-Tetrahydronaphthalene-2-carbonyl chloride → 4-{[Propyl-(4,5,6,7-tetrahydro-benzothiazol-6-yl)-amino]-methyl}-benzoyl chloride

HRID 1942398Notes

Reaction equation

HRID 1942398 reaction equation
[CH2:1]([N:4]([CH2:14][C:15]1[CH:23]=[CH:22][C:18]([C:19](O)=[O:20])=[CH:17][CH:16]=1)[CH:5]1[CH2:13][CH2:12][C:8]2[N:9]=[CH:10][S:11][C:7]=2[CH2:6]1)[CH2:2][CH3:3].C1C2C(=CC=CC=2)CCC1C([Cl:36])=O>>[CH2:1]([N:4]([CH2:14][C:15]1[CH:23]=[CH:22][C:18]([C:19]([Cl:36])=[O:20])=[CH:17][CH:16]=1)[CH:5]1[CH2:13][CH2:12][C:8]2[N:9]=[CH:10][S:11][C:7]=2[CH2:6]1)[CH2:2][CH3:3]

Participants

3

Reactant 2

HCID 156707901,2,3,4-Tetrahydronaphthalene-2-carbonyl chlorideHCID 669374084-{[Propyl-(4,5,6,7-tetrahydro-benzothiazol-6-yl)-amino]-methyl}-benzoic acid

Product 1

HCID 866513144-{[Propyl-(4,5,6,7-tetrahydro-benzothiazol-6-yl)-amino]-methyl}-benzoyl chloride

Procedure

4-{[Propyl-(4,5,6,7-tetrahydro-benzothiazol-6-yl)-amino]-methyl}-benzoyl chloride (42C) is prepared from 42B as described for 23A. The crude product is obtained in almost quantitative yield.

Sources & evidence

ORD record
ord-92e9c67b21054493a902f4115887bca1
Source dataset
uspto-grants-2013_03
Patent number
US08389555B2

Reaction notes

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