Potassium Iodide → 3-(4-(2-Methoxyphenyl)piperazin-1-yl)propan-1-ol

HRID 1942422Notes

Reaction equation

HRID 1942422 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]1[CH2:14][CH2:13][N:12]([CH2:15][CH2:16]O)[CH2:11][CH2:10]1.ClCC[CH2:21][OH:22].[I-].[K+]>CC(C)=O>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]1[CH2:10][CH2:11][N:12]([CH2:15][CH2:16][CH2:21][OH:22])[CH2:13][CH2:14]1

Participants

5

Reactant 3

HCID 4875Potassium IodideHCID 123133-Chloro-1-propanolHCID 111073541-Piperazineethanol, 4-(2-methoxyphenyl)-

Product 1

HCID 4109013-(4-(2-Methoxyphenyl)piperazin-1-yl)propan-1-olYield 46%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

3-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-propan-1-ol (29A) is prepared as described for 28A from 3-chloro-propan-1-ol with acetone as solvent and under addition of 1.66 g (10 mmol) potassium iodide. The mixture is heated to reflux.

Workup

  1. temperatureThe mixture is heated to reflux

Sources & evidence

ORD record
ord-4605d207bf54446eaa1dc04f83d25558
Source dataset
uspto-grants-2013_03
Patent number
US08389555B2

Reaction notes

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