4-Chloro-1-butanol → 4-(4-(2-Methoxyphenyl)piperazin-1-yl)butan-1-ol

HRID 1942425Notes

Reaction equation

HRID 1942425 reaction equation
ClCCC[CH2:5][OH:6].[CH3:7][O:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[N:15]1[CH2:20][CH2:19][N:18]([CH2:21][CH2:22][CH2:23]O)[CH2:17][CH2:16]1>>[CH3:7][O:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[N:15]1[CH2:16][CH2:17][N:18]([CH2:21][CH2:22][CH2:23][CH2:5][OH:6])[CH2:19][CH2:20]1

Participants

3

Reactant 2

HCID 135694-Chloro-1-butanolHCID 4109013-(4-(2-Methoxyphenyl)piperazin-1-yl)propan-1-ol

Product 1

HCID 148553204-(4-(2-Methoxyphenyl)piperazin-1-yl)butan-1-olYield 33%

Procedure

4-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-butan-1-ol (30A) is prepared from 4-chloro-butan-1-ol as described for 29A.

Sources & evidence

ORD record
ord-60677dc71dd84feaa976a93d63a45d84
Source dataset
uspto-grants-2013_03
Patent number
US08389555B2

Reaction notes

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