HCID 67332414, compound → HCID 67331189, compound

HRID 1942460Notes

Reaction equation

HRID 1942460 reaction equation
C(OC([NH:11][CH2:12][CH2:13][N:14]1[C:19]2[CH:20]=[C:21]([C:25]([N:27]([CH:41]([CH3:43])[CH3:42])[C@@H:28]3[CH2:33][CH2:32][CH2:31][N:30]([C:34]([O:36][C:37]([CH3:40])([CH3:39])[CH3:38])=[O:35])[CH2:29]3)=[O:26])[C:22]([CH3:24])=[CH:23][C:18]=2[O:17][C:16]([CH3:45])([CH3:44])[C:15]1=[O:46])=O)C1C=CC=CC=1>[C].[Pd].CO>[NH2:11][CH2:12][CH2:13][N:14]1[C:19]2[CH:20]=[C:21]([C:25]([N:27]([CH:41]([CH3:42])[CH3:43])[C@@H:28]3[CH2:33][CH2:32][CH2:31][N:30]([C:34]([O:36][C:37]([CH3:38])([CH3:40])[CH3:39])=[O:35])[CH2:29]3)=[O:26])[C:22]([CH3:24])=[CH:23][C:18]=2[O:17][C:16]([CH3:44])([CH3:45])[C:15]1=[O:46]

Participants

4

Reactant 1

HCID 67332414HCID 67332414, compound

Product 1

HCID 67331189HCID 67331189, compound

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

To tert-butyl (3R)-3-[{[4-(2-{[(benzyloxy)carbonyl]amino}ethyl)-2,2,7-trimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-6-yl]carbonyl}(isopropyl)amino]piperidine-1-carboxylate (1.14 g) were added a 10% palladium carbon (500 mg) and methanol (30 ml), and the mixture was stirred at room temperature under hydrogen atmosphere for 2 hours. After the reaction was complete, the mixture was filtered and concentrated. The obtained residue (900 mg) was used in the subsequent reaction without further treatment.

Workup

  1. filtrationthe mixture was filtered
  2. concentrationconcentrated
  3. customThe obtained residue (900 mg) was used in the subsequent reaction without further treatment

Sources & evidence

ORD record
ord-febafdd109bc4f92a7bc7468081837b8
Source dataset
uspto-grants-2013_03
Patent number
US08389511B2

Reaction notes

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