HCID 22116092, compound → HCID 58249669, compound

HRID 1942516Notes

Reaction equation

HRID 1942516 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][C:11]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[C:10]([C:20]([OH:22])=[O:21])[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]>CO.[C].[Pd]>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][C@H:11]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C@H:10]([C:20]([OH:22])=[O:21])[CH2:9]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 1

HCID 22116092HCID 22116092, compound

Product 1

HCID 58249669HCID 58249669, compoundYield 84%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

1-(tert-Butoxycarbonyl)-4-phenyl-1,2,5,6-tetrahydropyridin-3-carboxylic acid (5.63 g) was dissolved in methanol (60 ml), and thereto was added palladium-carbon (4.06 g), and the mixture was stirred under hydrogen atmosphere for 2 hours. The reaction solution was filtered on celite, and concentrated under reduced pressure to give the title compound (4.76 g).

Workup

  1. filtrationThe reaction solution was filtered on celite
  2. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-749f8d62bca74c88a13bd610b23eea9e
Source dataset
uspto-grants-2013_03
Patent number
US08389511B2

Reaction notes

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