1,4-Dioxane hydrochloride → HCID 67330264, compound

HRID 1942561Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][C:10]=1[C:11]([N:13]([CH:27]([CH3:29])[CH3:28])[C@@H:14]1[CH2:19][CH2:18][CH2:17][N:16](C(OC(C)(C)C)=O)[CH2:15]1)=[O:12])[N:7]([CH2:30][CH2:31][CH2:32][CH2:33][O:34][CH3:35])[C:6](=[O:36])[C:5]2([CH3:38])[CH3:37].Cl.O1CCOCC1>O1CCOCC1>[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][C:10]=1[C:11]([N:13]([CH:27]([CH3:28])[CH3:29])[C@@H:14]1[CH2:19][CH2:18][CH2:17][NH:16][CH2:15]1)=[O:12])[N:7]([CH2:30][CH2:31][CH2:32][CH2:33][O:34][CH3:35])[C:6](=[O:36])[C:5]2([CH3:38])[CH3:37]

Participants

Conditions

Temperature: 25 °C

Procedure

To a solution of tert-butyl (3R)-3-[{[5-chloro-1-(4-methoxybutyl)-3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-6-yl]carbonyl}(isopropyl)amino]piperidine-1-carboxylate (100 mg) in 1,4-dioxane (3 ml) was added a 4N hydrochloric acid/dioxane solution (2 ml), and the mixture was stirred at 25° C. for 2 hours, and concentrated under reduced pressure to give the title compound (70 mg).

Workup

concentrationconcentrated under reduced pressure

Sources & evidence

ORD record: ord-43eca98bb60c415c9950f0e7e006640e
Source dataset: uspto-grants-2013_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08389511B2

Reaction notes

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