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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1942561Generated: November 2, 2026

1,4-Dioxane hydrochloride → HCID 67330264, compound

https://huagongshe.com/reaction/1942561

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,4-Dioxane hydrochlorideHCID 20443148—
ReactantHCID 67333300HCID 67333300—
Solvent1,4-DioxaneHCID 31275—
ProductHCID 67330264HCID 67330264158.3%

Reaction Conditions

Temperature25 °C

Reaction Steps

To a solution of tert-butyl (3R)-3-[{[5-chloro-1-(4-methoxybutyl)-3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-6-yl]carbonyl}(isopropyl)amino]piperidine-1-carboxylate (100 mg) in 1,4-dioxane (3 ml) was added a 4N hydrochloric acid/dioxane solution (2 ml), and the mixture was stirred at 25° C. for 2 hours, and concentrated under reduced pressure to give the title compound (70 mg).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08389511B2
Source datasetuspto-grants-2013_03
ORD IDord-43eca98bb60c415c9950f0e7e006640e
Source noteuspto-grants-2013_03