HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1942561Generated: November 2, 2026
1,4-Dioxane hydrochloride → HCID 67330264, compound
https://huagongshe.com/reaction/1942561
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1,4-Dioxane hydrochloride | HCID 20443148 | — |
| Reactant | HCID 67333300 | HCID 67333300 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 67330264 | HCID 67330264 | 158.3% |
Reaction Steps
To a solution of tert-butyl (3R)-3-[{[5-chloro-1-(4-methoxybutyl)-3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-6-yl]carbonyl}(isopropyl)amino]piperidine-1-carboxylate (100 mg) in 1,4-dioxane (3 ml) was added a 4N hydrochloric acid/dioxane solution (2 ml), and the mixture was stirred at 25° C. for 2 hours, and concentrated under reduced pressure to give the title compound (70 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08389511B2 |
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| Source dataset | uspto-grants-2013_03 |
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| ORD ID | ord-43eca98bb60c415c9950f0e7e006640e |
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| Source note | uspto-grants-2013_03 |
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