1,4-Dioxane hydrochloride → HCID 67331169, compound

HRID 1942562Notes

Reaction equation

HRID 1942562 reaction equation
[F:1][CH:2]([F:41])[C:3]([NH:5][CH2:6][CH2:7][N:8]1[C:13]2[CH:14]=[C:15]([C:19]([N:21]([CH:35]([CH3:37])[CH3:36])[C@@H:22]3[CH2:27][CH2:26][CH2:25][N:24](C(OC(C)(C)C)=O)[CH2:23]3)=[O:20])[C:16]([CH3:18])=[CH:17][C:12]=2[S:11][C:10]([CH3:39])([CH3:38])[C:9]1=[O:40])=[O:4].[ClH:42].O1CCOCC1>C(Cl)(Cl)Cl>[ClH:42].[F:41][CH:2]([F:1])[C:3]([NH:5][CH2:6][CH2:7][N:8]1[C:13]2[CH:14]=[C:15]([C:19]([N:21]([CH:35]([CH3:36])[CH3:37])[C@@H:22]3[CH2:27][CH2:26][CH2:25][NH:24][CH2:23]3)=[O:20])[C:16]([CH3:18])=[CH:17][C:12]=2[S:11][C:10]([CH3:39])([CH3:38])[C:9]1=[O:40])=[O:4]

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 58375812HCID 58375812, compound

Product 1

HCID 67331169HCID 67331169, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

To a solution of tert-butyl (3R)-3-[[(4-{2-[(difluoroacetyl)amino]ethyl}-2,2,7-trimethyl-3-oxo-3,4-dihydro-2H-1,4-benzothiazin-6-yl)carbonyl](isopropyl)amino]piperidine-1-carboxylate (1 g) in chloroform (8 ml) was added a 4N hydrochloric acid/dioxane solution (8 ml), and the mixture was stirred at room temperature for one hour. The mixture was concentrated under reduced pressure to give the title compound (0.9 g).

Workup

  1. concentrationThe mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-577fb9cb190e467a844b6508d61d33fe
Source dataset
uspto-grants-2013_03
Patent number
US08389511B2

Reaction notes

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