Methanol → HCID 67331749, compound

HRID 1942563Notes

Reaction equation

HRID 1942563 reaction equation
[CH:1]([N:4]([C:18]([C:20]1[C:21]([CH3:41])=[CH:22][C:23]2[S:31][C:27]3([CH2:30][CH2:29][CH2:28]3)[C:26](=[O:32])[N:25]([CH2:33][CH2:34][NH:35][C:36](=[O:39])[CH2:37][CH3:38])[C:24]=2[CH:40]=1)=[O:19])[C@@H:5]1[CH2:10][CH2:9][CH2:8][N:7](C(OC(C)(C)C)=O)[CH2:6]1)([CH3:3])[CH3:2].CO.[ClH:44].O1CCOCC1>C(Cl)(Cl)Cl>[ClH:44].[CH:1]([N:4]([C@@H:5]1[CH2:10][CH2:9][CH2:8][NH:7][CH2:6]1)[C:18]([C:20]1[C:21]([CH3:41])=[CH:22][C:23]2[S:31][C:27]3([CH2:28][CH2:29][CH2:30]3)[C:26](=[O:32])[N:25]([CH2:33][CH2:34][NH:35][C:36](=[O:39])[CH2:37][CH3:38])[C:24]=2[CH:40]=1)=[O:19])([CH3:2])[CH3:3]

Participants

5

Reactant 3

HCID 887MethanolHCID 204431481,4-Dioxane hydrochlorideHCID 58376381HCID 58376381, compound

Product 1

HCID 67331749HCID 67331749, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

To a solution of tert-butyl (3R)-3-[isopropyl({7-methyl-3-oxo-4-[2-(propionylamino)ethyl]-3,4-dihydrospiro[1,4-benzothiazine-2,1′-cyclobutan]-6-yl}carbonyl)amino]piperidine-1-carboxylate (2.5 g) in chloroform (7 ml)-methanol (15 ml) was added a 4N hydrochloric acid/dioxane solution (21 ml), and the mixture was stirred at room temperature for one hour. The mixture was concentrated under reduced pressure to give the title compound (2.2 g).

Workup

  1. concentrationThe mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-f60c832860dc4236b5def6383b419ac9
Source dataset
uspto-grants-2013_03
Patent number
US08389511B2

Reaction notes

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