Hydrochloric Acid → [3-(2-{3-Chloro-4-[(1-methylethyl)oxy]phenyl}-1,3-thiazol-5-yl)-2-ethylphenyl]acetaldehyde

Participants

Reaction Conditions

Reaction Steps

To a mixture of 2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-5-{2-ethyl-3-[(E)-2-(methyloxy)ethenyl]phenyl}-1,3-thiazole (D77) (500 mg) in tetrahydrofuran (THF) (100 mL) under nitrogen was added HCl (0.805 mL). The reaction was heated to 75° C. for 3 h. The mixture was concentrated to give the crude product [3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,3-thiazol-5-yl)-2-ethylphenyl]acetaldehyde (D78) (483 mg) as a brown oil. MS (ES): C22H22ClNO2S requires 399. found 400.1 (M+H+).

Provenance & Evidence