HRID1942649
反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
AUXILIARIES
试剂、催化剂与溶剂
CONDITIONS
反应条件
- 温度
- 75 °C
PROCEDURE
实验过程
To a mixture of 2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-5-{2-ethyl-3-[(E)-2-(methyloxy)ethenyl]phenyl}-1,3-thiazole (D77) (500 mg) in tetrahydrofuran (THF) (100 mL) under nitrogen was added HCl (0.805 mL). The reaction was heated to 75° C. for 3 h. The mixture was concentrated to give the crude product [3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,3-thiazol-5-yl)-2-ethylphenyl]acetaldehyde (D78) (483 mg) as a brown oil. MS (ES): C22H22ClNO2S requires 399. found 400.1 (M+H+).
WORKUP
后处理
- concentrationThe mixture was concentrated