反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
AUXILIARIES
试剂、催化剂与溶剂
CONDITIONS
反应条件
- 温度
- 120 °C
PROCEDURE
实验过程
To a solution of 1,1-dimethylethyl 4-[2-ethyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-1-piperidinecarboxylate (70 mg, 0.169 mmol), 5-(3-bromo-1,2,4-thiadiazol-5-yl)-2-(2-methylpropyl)benzonitrile (D60) (81 mg, 0.253 mmol) and Pd(Ph3P)4 (19.47 mg, 0.017 mmol) in N,N-Dimethylformamide (DMF) (5 mL) and Water (1 mL) was added tripotassium phosphate (107 mg, 0.506 mmol). This solution was stirred in MW irradiation at 120° C. for 20 Min. The solution was dried directly with silica gel and purified on column chromatography to afford 1,1-dimethylethyl 4-(3-{5-[3-cyano-4-(2-methylpropyl)phenyl]-1,2,4-thiadiazol-3-yl}-2-ethylphenyl)-1-piperidinecarboxylate (D124) (89 mg). MS (ES): C31H38N4O2S requires 530.3. found 531.3 (M+H+).
WORKUP
后处理
- customThe solution was dried directly with silica gel
- custompurified on column chromatography