Trifluoroacetic acid → 5-{3-[2-Ethyl-3-(4-piperidinyl)phenyl]-1,2,4-thiadiazol-5-yl}-2-(2-methylpropyl)benzonitrile

HRID 1942690Notes

Reaction equation

HRID 1942690 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]([C:13]2[S:17][N:16]=[C:15]([C:18]3[C:19]([CH2:37][CH3:38])=[C:20]([CH:24]4[CH2:29][CH2:28][N:27](C(OC(C)(C)C)=O)[CH2:26][CH2:25]4)[CH:21]=[CH:22][CH:23]=3)[N:14]=2)[CH:6]=[CH:7][C:8]=1[CH2:9][CH:10]([CH3:12])[CH3:11])#[N:2].C(O)(C(F)(F)F)=O>ClCCl>[CH2:37]([C:19]1[C:20]([CH:24]2[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]2)=[CH:21][CH:22]=[CH:23][C:18]=1[C:15]1[N:14]=[C:13]([C:5]2[CH:6]=[CH:7][C:8]([CH2:9][CH:10]([CH3:11])[CH3:12])=[C:3]([CH:4]=2)[C:1]#[N:2])[S:17][N:16]=1)[CH3:38]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 58494079HCID 58494079, compound

Product 1

HCID 584940155-{3-[2-Ethyl-3-(4-piperidinyl)phenyl]-1,2,4-thiadiazol-5-yl}-2-(2-methylpropyl)benzonitrileYield 99.5%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 1,1-dimethylethyl 4-(3-{5-[3-cyano-4-(2-methylpropyl)phenyl]-1,2,4-thiadiazol-3-yl}-2-ethylphenyl)-1-piperidinecarboxylate (D124) (0.089 g, 0.168 mmol) in Dichloromethane (DCM) (10 mL) at room temp was added TFA (0.388 mL, 5.04 mmol). This solution was stirred for 2 hr. This solution was condensed and dried in high vacuum to remove TFA to afford 5-{3-[2-ethyl-3-(4-piperidinyl)phenyl]-1,2,4-thiadiazol-5-yl}-2-(2-methylpropyl)benzonitrile (D125) (72 mg) as a brown oil residue, which was used directly in the next step. MS (ES): C26H30N4S requires 430.2. found 431.2 (M+H+).

Workup

  1. customcondensed
  2. customdried in high vacuum
  3. customto remove TFA

Sources & evidence

ORD record
ord-21e8fe9ee979450f8d0d434233bf80cb
Source dataset
uspto-grants-2013_03
Patent number
US08389508B2

Reaction notes

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