反应详情

To a solution of 1-(3-(5-(3-chloro-4-isopropoxyphenyl)-1,3,4-thiadiazol-2-yl)-2-ethylbenzyl)azetidine-3-carboxylic acid (100 mg, 0.212 mmol) in THF (2 mL) was added H2SO4 (0.286 mL, 4%, aq. solution). The mixture became clear and stirred for 30 min at rt. The solution was concentrated under the reduced pressure and dried in vacuum to give 3-carboxy-1-(3-(5-(3-chloro-4-isopropoxyphenyl)-1,3,4-thiadiazol-2-yl)-2-ethylbenzyl)azetidin-1-ium hydrogensulfate (123 mg) as pale yellow crystalline solid.

1. concentrationThe solution was concentrated under the reduced pressure
2. customdried in vacuum