反应详情

TFA (1 ml, 12.98 mmol) was added to a suspension of 302 (0.093 g, 0.128 mmol) in DCM (1.000 ml) and the mixture was stirred at room temperature for 2 h. The reaction mixture was then concentrated under reduced pressure, the residue was dissolved in DCM, washed with 1N NaOH solution, water, dried over anhydrous sodium sulfate and concentrated affording title compound 303 (0.0714 g, 0.109 mmol, 85% yield) as white solid.

1. concentrationThe reaction mixture was then concentrated under reduced pressure
2. dissolutionthe residue was dissolved in DCM
3. washwashed with 1N NaOH solution, water
4. dry with materialdried over anhydrous sodium sulfate
5. concentrationconcentrated