2-Trifluoromethylphenol → HCID 59278667, compound

HRID 1942881Notes

Reaction equation

HRID 1942881 reaction equation
Cl[C:2]1[N:7]=[CH:6][N:5]=[C:4]([NH:8][C:9]2[CH:14]=[CH:13][C:12]([N:15]3[CH:19]=[C:18]([CH3:20])[N:17]=[CH:16]3)=[C:11]([O:21][CH3:22])[CH:10]=2)[N:3]=1.[OH:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=1[C:30]([F:33])([F:32])[F:31]>C(OCC)(=O)C>[CH3:22][O:21][C:11]1[CH:10]=[C:9]([NH:8][C:4]2[N:3]=[C:2]([O:23][C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=3[C:30]([F:31])([F:32])[F:33])[N:7]=[CH:6][N:5]=2)[CH:14]=[CH:13][C:12]=1[N:15]1[CH:19]=[C:18]([CH3:20])[N:17]=[CH:16]1

Participants

4

Reactant 2

HCID 679582-TrifluoromethylphenolHCID 86640784HCID 86640784, compound

Product 1

HCID 59278667HCID 59278667, compoundYield 33%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

This compound was prepared from (4-chloro-[1,3,5]triazin-2-yl)-[3-methoxy-4-(4-methyl-imidazol-1-yl)-phenyl]-amine and 2-hydroxybenzotrifluoride in analogy to example 3. Chromatography on silica gel using ethyl acetate as an eluent gave the title compound as a colorless solid in 33% yield.

Sources & evidence

ORD record
ord-125a6879ca5e4727b444bd4d16a4e339
Source dataset
uspto-grants-2013_03
Patent number
US08389717B2

Reaction notes

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