4-Chloro-N-methylbenzenamine → HCID 45275193, compound

HRID 1942882Notes

Reaction equation

HRID 1942882 reaction equation
Cl[C:2]1[N:7]=[CH:6][N:5]=[C:4]([NH:8][C:9]2[CH:14]=[CH:13][C:12]([N:15]3[CH:19]=[C:18]([CH3:20])[N:17]=[CH:16]3)=[C:11]([O:21][CH3:22])[CH:10]=2)[N:3]=1.[Cl:23][C:24]1[CH:31]=[CH:30][C:27]([NH:28][CH3:29])=[CH:26][CH:25]=1>C(OCC)(=O)C>[Cl:23][C:24]1[CH:31]=[CH:30][C:27]([N:28]([CH3:29])[C:2]2[N:3]=[C:4]([NH:8][C:9]3[CH:14]=[CH:13][C:12]([N:15]4[CH:19]=[C:18]([CH3:20])[N:17]=[CH:16]4)=[C:11]([O:21][CH3:22])[CH:10]=3)[N:5]=[CH:6][N:7]=2)=[CH:26][CH:25]=1

Participants

4

Reactant 2

HCID 702724-Chloro-N-methylbenzenamineHCID 86640784HCID 86640784, compound

Product 1

HCID 45275193HCID 45275193, compoundYield 23%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

This compound was prepared from (4-chloro-[1,3,5]triazin-2-yl)-[3-methoxy-4-(4-methyl-imidazol-1-yl)-phenyl]-amine and 4-chloro-N-methylaniline in analogy to example 1c. Chromatography on Si—NH2 gel (Isolute) using ethyl acetate as an eluent gave the title compound as a colorless solid in 23% yield.

Sources & evidence

ORD record
ord-6ab287bce14a4784859827d314ed78dc
Source dataset
uspto-grants-2013_03
Patent number
US08389717B2

Reaction notes

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