2-Trifluoromethylphenol → HCID 45275081, compound

HRID 1942888Notes

Reaction equation

HRID 1942888 reaction equation
Cl[C:2]1[N:7]=[C:6]([O:8][CH:9]([CH3:11])[CH3:10])[N:5]=[C:4]([NH:12][C:13]2[CH:18]=[CH:17][C:16]([N:19]3[CH:23]=[C:22]([CH3:24])[N:21]=[CH:20]3)=[C:15]([O:25][CH3:26])[CH:14]=2)[N:3]=1.[OH:27][C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=1[C:34]([F:37])([F:36])[F:35]>C(OCC)(=O)C>[CH:9]([O:8][C:6]1[N:7]=[C:2]([O:27][C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=2[C:34]([F:35])([F:36])[F:37])[N:3]=[C:4]([NH:12][C:13]2[CH:18]=[CH:17][C:16]([N:19]3[CH:23]=[C:22]([CH3:24])[N:21]=[CH:20]3)=[C:15]([O:25][CH3:26])[CH:14]=2)[N:5]=1)([CH3:11])[CH3:10]

Participants

4

Reactant 2

HCID 679582-TrifluoromethylphenolHCID 86640785HCID 86640785, compound

Product 1

HCID 45275081HCID 45275081, compoundYield 99%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

This compound was prepared from (4-chloro-6-isopropoxy-[1,3,5]triazin-2-yl)-[3-methoxy-4-(4-methyl-imidazol-1-yl)-phenyl]-amine and 2-hydroxy benzotrifluoride in analogy to example 3. Chromatography on silica gel using ethyl acetate as an eluent gave the title compound as a colorless solid in 99% yield.

Sources & evidence

ORD record
ord-c317150522e2499bb04bec916b72503a
Source dataset
uspto-grants-2013_03
Patent number
US08389717B2

Reaction notes

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