Potassium Carbonate → HCID 45275189, compound

HRID 1942896Notes

Reaction equation

HRID 1942896 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]([F:11])([F:10])[F:9].[C:12](=[O:15])([O-])[O-].[K+].[K+].Cl[C:19]1[N:24]=[C:23](Cl)[N:22]=[C:21]([NH:26][C:27]2[CH:32]=[CH:31][C:30]([N:33]3[CH:37]=[C:36]([CH3:38])[N:35]=[CH:34]3)=[C:29]([O:39][CH3:40])[CH:28]=2)[N:20]=1>C(#N)C.O>[F:11][C:8]([F:9])([F:10])[C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[O:1][C:19]1[N:24]=[C:23]([O:15][C:12]2[CH:5]=[CH:6][CH:7]=[CH:2][C:3]=2[C:8]([F:11])([F:10])[F:9])[N:22]=[C:21]([NH:26][C:27]2[CH:32]=[CH:31][C:30]([N:33]3[CH:37]=[C:36]([CH3:38])[N:35]=[CH:34]3)=[C:29]([O:39][CH3:40])[CH:28]=2)[N:20]=1

Participants

6

Reactant 3

HCID 11430Potassium CarbonateHCID 679582-TrifluoromethylphenolHCID 87317448HCID 87317448, compound

Product 1

HCID 45275189HCID 45275189, compoundYield 10%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6342AcetonitrileSolvent

Procedure

A mixture of 2-hydroxybenzotrifluoride (95 mg, 0.59 mmol) and potassium carbonate (87 mg, 0.63 mmol) in 10 ml of acetonitrile was treated with (4,6-dichloro-[1,3,5]triazin-2-yl)-[3-methoxy-4-(4-methyl-imidazol-1-yl)-phenyl]-amine. The suspension was refluxed overnight, diluted with water and extracted with ethyl acetate. Chromatography on silica gel using ethyl acetate as the eluent gave the title compound (17 mg, 10%) as a slightly brownish solid.

Workup

  1. temperatureThe suspension was refluxed overnight
  2. extractionextracted with ethyl acetate

Sources & evidence

ORD record
ord-0efd555711de4c778f22c2cc0a9eb1f5
Source dataset
uspto-grants-2013_03
Patent number
US08389717B2

Reaction notes

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