(R)-2-(Methylamino)-2-phenylethanol → HCID 59278674, compound

HRID 1942906Notes

Reaction equation

HRID 1942906 reaction equation
Cl[C:2]1[N:7]=[C:6]([O:8][CH3:9])[N:5]=[C:4]([NH:10][C:11]2[CH:16]=[CH:15][C:14]([N:17]3[CH:21]=[C:20]([CH3:22])[N:19]=[CH:18]3)=[C:13]([O:23][CH3:24])[CH:12]=2)[N:3]=1.[CH3:25][NH:26][C@H:27]([C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)[CH2:28][OH:29]>>[CH3:9][O:8][C:6]1[N:5]=[C:4]([NH:10][C:11]2[CH:16]=[CH:15][C:14]([N:17]3[CH:21]=[C:20]([CH3:22])[N:19]=[CH:18]3)=[C:13]([O:23][CH3:24])[CH:12]=2)[N:3]=[C:2]([N:26]([CH3:25])[C@@H:27]([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[CH2:28][OH:29])[N:7]=1

Participants

3

Reactant 2

HCID 11030005(R)-2-(Methylamino)-2-phenylethanolHCID 86640783(4-Chloro-6-methoxy-[1,3,5]triazin-2-yl)-[3-methoxy-4-(4-methyl-imidazol-1-yl)-phenyl]-amine

Product 1

HCID 59278674HCID 59278674, compoundYield 32%

Procedure

This compound was prepared from (4-chloro-6-methoxy-[1,3,5]triazin-2-yl)-[3-methoxy-4-(4-methyl-imidazol-1-yl)-phenyl]-amine and (R)-2-methylamino-2-phenyl-ethanol in analogy to example 1c. Purification by chromatography on Si—NH2 gel (Isolute) using ethyl acetate as an eluent gave the title compound as a colorless solid in 32% yield.

Workup

  1. customPurification by chromatography on Si—NH2 gel (Isolute)

Sources & evidence

ORD record
ord-ffc93e33f0c448c68b2d505ecbb3e869
Source dataset
uspto-grants-2013_03
Patent number
US08389717B2

Reaction notes

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