Triethylamine → HCID 59278684, compound

HRID 1942910Notes

Reaction equation

HRID 1942910 reaction equation
Cl[C:2]1[N:7]=[C:6]([Cl:8])[N:5]=[C:4]([CH2:9][C:10]2[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][CH:11]=2)[N:3]=1.[CH3:17][O:18][C:19]1[CH:20]=[C:21]([NH2:31])[CH:22]=[CH:23][C:24]=1[N:25]1[CH:29]=[C:28]([CH3:30])[N:27]=[CH:26]1.C(N(CC)CC)C>CO>[Cl:8][C:6]1[N:5]=[C:4]([CH2:9][C:10]2[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][CH:11]=2)[N:3]=[C:2]([NH:31][C:21]2[CH:22]=[CH:23][C:24]([N:25]3[CH:29]=[C:28]([CH3:30])[N:27]=[CH:26]3)=[C:19]([O:18][CH3:17])[CH:20]=2)[N:7]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 454801813-methoxy-4-(4-methyl-1H-imidazol-1-yl)anilineHCID 86640789HCID 86640789, compound

Product 1

HCID 59278684HCID 59278684, compoundYield 42.9%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
5 °C

Procedure

2,4-Dichloro-6-(4-chloro-benzyl)-[1,3,5]triazine (0.78 g, 2.8 mmol) was added at 5° C. to a solution of 3-methoxy-4-(4-methyl-imidazol-1-yl)-phenylamine (0.61 g, 3.0 mmol) and triethylamine (0.36 ml, 0.26 mmol) in 15 ml of methanol. The mixture was stirred at 5° C. for 1 h and thereafter evaporated under reduced pressure. The residual material was purified by chromatography on silica gel using heptane/0-100% ethyl acetate as eluent to give the title compound (0.53 g, 40%) as a yellow viscous oil.

Workup

  1. customevaporated under reduced pressure
  2. customThe residual material was purified by chromatography on silica gel

Sources & evidence

ORD record
ord-8806668fd75b4af294bf01cc127510c1
Source dataset
uspto-grants-2013_03
Patent number
US08389717B2

Reaction notes

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