Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Citric Acid | HCID 311 | — |
| Reactant | Sitagliptin | HCID 4369359 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | HCID 86640094 | HCID 86640094 | — |
Reaction Steps
Sitagliptin base (150 mg) was suspended in 2-propanol (2.5 mL). Citric acid (71 mg) was added and the mixture was stirred for one hour at ambient temperature and 2 hours at 40° C. The mixture was allowed to cool to ambient temperature and stirred for 24 hours at this temperature. The solid was filtered and dried at ambient temperature.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08389724B2 |
|---|
| Source dataset | uspto-grants-2013_03 |
|---|
| ORD ID | ord-e8552106ff7f4844aa6f3034502face1 |
|---|
| Source note | uspto-grants-2013_03 |
|---|
