反应详情

温度

40 °C

Sitagliptin base (150 mg) was suspended in 2-propanol (2.5 mL). Citric acid (71 mg) was added and the mixture was stirred for one hour at ambient temperature and 2 hours at 40° C. The mixture was allowed to cool to ambient temperature and stirred for 24 hours at this temperature. The solid was filtered and dried at ambient temperature.

1. temperatureto cool to ambient temperature
2. stirringstirred for 24 hours at this temperature
3. filtrationThe solid was filtered
4. customdried at ambient temperature