反应详情

To phenyl(tetrahydro-4H-pyran-4-ylidene)acetonitrile (450 mg, 2.258 mmol) in ethanol (11 ml) was added HCl (12.1 M, 1.867 ml, 22.58 mmol) then 10% Pd/C (48.1 mg, 0.045 mmol) as a slurry in ethanol. The reaction mixture was put under H2 balloon pressure for 21 hours. The reaction was filtered through a 0.45 um syringe-tip filter, then concentrated in vacuo. The product was used without further purification.

1. customfor 21 hours
2. filtrationThe reaction was filtered through a 0.45 um syringe-tip
3. filtrationfilter
4. concentrationconcentrated in vacuo
5. customThe product was used without further purification