反应详情

1-methyl-2-oxo-1,2-dihydroquinoline-3-carbaldehyde (0.590 g, 3.15 mmol), tert-butyl 4-(2-amino-1-phenylethyl)piperidine-1-carboxylate (1.2 g crude, 3.94 mmol), and acetic acid (0.677 ml, 11.83 mmol) were combined in CH2Cl2 (20 ml). Sodium triacetoxyborohydride (2.506 g, 11.83 mmol) was added and the reaction stirred for 16 hours. The mixture was partitioned between CH2Cl2 and satd. bicarb, the aqueous portion extracted 3×CH2Cl2, and the organic portion dried (Na2SO4) then concentrated in vacuo. The product was carried on without further purification.

1. customThe mixture was partitioned between CH2Cl2 and satd
2. extractionbicarb, the aqueous portion extracted 3×CH2Cl2
3. dry with materialthe organic portion dried (Na2SO4)
4. concentrationthen concentrated in vacuo
5. customThe product was carried on without further purification