HRID1943028

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

HCID31275

1,4-Dioxane

C4H8O2

结构：Cn1c(=O)c(CN(CC(c2ccccc2)C2CCN(C(=O)OC(C)(C)C)CC2)C(=O)C2CCCCC2)cc2ccccc21

HCID58415912

未命名化合物

PRODUCTS

生成物

结构：Cn1c(=O)c(CN(CC(c2ccccc2)C2CCNCC2)C(=O)C2CCCCC2)cc2ccccc21

HCID58415916

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

tert-butyl 4-(2-{(cyclohexylcarbonyl) [(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]amino}-1-phenylethyl)piperidine-1-carboxylate (1.63 g, 2.78 mmol) in CH2Cl2 (5 ml) was added to 4 M HCl in dioxane (20 mL, 80 mmol) at 0° C. and the reaction stirred for 1.5 hours before being poured into satd. bicarb. The mixture was partitioned between CH2Cl2 and satd. bicarb, the aqueous portion extracted 3×CH2Cl2, and the organic portion dried (Na2SO4) then concentrated in vacuo. 1.35 g, 100%.

WORKUP

后处理

additionbefore being poured into satd
customThe mixture was partitioned between CH2Cl2 and satd
extractionbicarb, the aqueous portion extracted 3×CH2Cl2
dry with materialthe organic portion dried (Na2SO4)
concentrationthen concentrated in vacuo

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-5b94c9b4a02f416eaa0794e4953b0138
来源数据集: uspto-grants-2013_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08389720B2
来源说明: uspto-grants-2013_03

反应 SMILES

[CH:1]1([C:7]([N:9]([CH2:31][C:32]2[C:33](=[O:43])[N:34]([CH3:42])[C:35]3[C:40]([CH:41]=2)=[CH:39][CH:38]=[CH:37][CH:36]=3)[CH2:10][CH:11]([CH:18]2[CH2:23][CH2:22][N:21](C(OC(C)(C)C)=O)[CH2:20][CH2:19]2)[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[O:8])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.Cl.O1CCOCC1>C(Cl)Cl>[CH3:42][N:34]1[C:35]2[C:40](=[CH:39][CH:38]=[CH:37][CH:36]=2)[CH:41]=[C:32]([CH2:31][N:9]([CH2:10][CH:11]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:18]2[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]2)[C:7]([CH:1]2[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]2)=[O:8])[C:33]1=[O:43]