Acetic Acid → HCID 58415922, compound

Participants

Reaction Steps

1-methyl-2-oxo-1,2-dihydroquinoline-3-carbaldehyde (35 mg, 0.187 mmol), sodium acetate (19.94 mg, 0.243 mmol), and 1-(2-ammonio-1-phenylethyl)-4,4-difluoropiperidinium dichloride (51.7 mg, 0.187 mmol) were combined in 1,2-dichloroethane (2 ml). Acetic acid (0.021 ml, 0.374 mmol) and sodium triacetoxyborohydride (119 mg, 0.561 mmol) were added and the reaction stirred for 1 hour. The reaction mixture was partitioned between CH2Cl2 and satd. bicarb, the aqueous portion extracted 3×CH2Cl2, and the organic portion dried (Na2SO4) then concentrated in vacuo. The material was carried on without further purification.

Provenance & Evidence